Description

Felodipine-D5 is a deuterated analog of the calcium channel blocker felodipine, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities to ensure accuracy and reliability in method development and validation.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of felodipine in complex biological matrices like plasma, serum, and urine.
• Metabolite Tracing & Pharmacokinetics: Enables detailed studies of drug absorption, distribution, metabolism, and excretion (ADME) using mass spectrometry.
• Method Development & Validation: Serves as a key component in developing and validating robust, regulatory-compliant bioanalytical assays.
• Drug Impurity Profiling: Used as a reference marker in the identification and quantification of process-related impurities or degradants.
• Clinical Research: Supports therapeutic drug monitoring and bioequivalence studies in clinical trial settings.
• Quality Control in Manufacturing: Acts as a calibration standard to ensure the potency and purity of active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Felodipine-D5
CAS No.	1242281-38-4
Molecular Formula	C18H14D5Cl2NO4
Molecular Weight	387.28 g/mol
Synonyms	Felodipine-d5; [2H5]-Felodipine; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 1-methylethyl 5-methyl ester-d5; Deuterated Felodipine; Felodipine (phenyl-d5); Felodipine Internal Standard; Isotopically Labeled Felodipine; Felodipine-D5 Standard
EINECS	Contact for details

Quality Control

Our Felodipine-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with the stringent requirements of pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.