Description

(R)-Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate is a high-value, chiral piperazine derivative serving as a critical advanced pharmaceutical intermediate (API) and building block in organic synthesis. Its primary value lies in its role as a key chiral precursor for the development of complex, biologically active molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on creating new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the chiral 2-cyanopiperazine scaffold into novel drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis to construct complex molecules with high enantiomeric purity.
• Peptidomimetics Development: The piperazine core is integral for creating peptidomimetic compounds that mimic peptides but with enhanced metabolic stability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.
• Agrochemical Research: Potential application as an intermediate in the development of novel chiral agrochemicals, such as herbicides or fungicides.

Basic Information

Product Name	(R)-Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate
CAS No.	1242267-78-2
Molecular Formula	C15H25N3O4
Molecular Weight	311.38 g/mol
Synonyms	1,4-Piperazinedicarboxylic acid, 2-cyano-, 1,4-bis(1,1-dimethylethyl) ester, (2R)-; (R)-1,4-Di-tert-butyl 2-cyanopiperazine-1,4-dicarboxylate; (R)-2-Cyano-1,4-di-tert-butyl piperazine-1,4-dicarboxylate; (R)-Boc-Boc-2-cyanopiperazine; (R)-2-CN-Pip(Boc)2; (R)-DiBoc-2-cyanopiperazine; (S)-Enantiomer of Di-tert-butyl 2-cyanopiperazine-1,4-dicarboxylate (Related); Chiral 2-Cyanopiperazine Derivative
EINECS	Contact for details

Quality Control

Our (R)-Di-tert-Butyl 2-Cyanopiperazine-1,4-Dicarboxylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling and chiral analysis to confirm enantiomeric excess (ee). A detailed Certificate of Analysis (COA) documenting identity, purity, and specific tests is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.