Description

2-Bromo-1-Fluoro-3-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethoxy substituent, makes it a versatile intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and for introducing fluorine atoms into organic molecules to modulate lipophilicity, metabolic stability, and bioavailability.
• Contract Research & Manufacturing (CRAM): Supplied to custom synthesis organizations for use in client-directed projects requiring specialized fluorinated intermediates.

Basic Information

Product Name	2-Bromo-1-Fluoro-3-(Trifluoromethoxy)Benzene
CAS No.	1242249-84-8
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	1-Bromo-2-fluoro-3-(trifluoromethoxy)benzene; 2-Fluoro-6-(trifluoromethoxy)bromobenzene; 3-Bromo-2-fluoroanisole, 1,1,1-trifluoro; Benzene, 2-bromo-1-fluoro-3-(trifluoromethoxy)-; 2-Bromo-1-fluoro-3-(trifluoromethoxy)benzene; 2-Fluoro-6-trifluoromethoxybromobenzene; 3-Bromo-2-fluoro-α,α,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Fluoro-3-(Trifluoromethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.