Description

1-Bromo-3-(Difluoromethoxy)-2-Fluoro-Benzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique molecular architecture, which introduces bromine, fluorine, and difluoromethoxy substituents in precise positions, enabling the development of novel materials and active compounds. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for creating next-generation products with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs that can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoromethoxy and halogen groups contribute to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic displays and optoelectronic devices.
• Polymer Modification: Employed to incorporate halogen and fluorine functionalities into polymer backbones, altering physical properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl structures.
• Organic Synthesis Building Block: Provides a versatile template for further functionalization in medicinal and materials chemistry research programs.

Basic Information

Item	Details
Product Name	1-Bromo-3-(Difluoromethoxy)-2-Fluoro-Benzene
CAS No.	1242249-28-0
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	2-Fluoro-3-bromo-α,α-difluoroanisole; 3-Bromo-2-fluoro-α,α-difluoroanisole; 1-Bromo-3-(difluoromethoxy)-2-fluorobenzene; 2-Fluoro-α,α-difluoro-3-bromoanisole; Benzene, 1-bromo-3-(difluoromethoxy)-2-fluoro-; 3-Bromo-2-fluoroanisole, α,α-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-(Difluoromethoxy)-2-Fluoro-Benzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.7 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.