Description

Diltiazem-D6 is a deuterium-labeled analog of the calcium channel blocker Diltiazem, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and forensic toxicology sectors who require precise and traceable reference materials.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of Diltiazem in biological matrices (plasma, serum, urine) and pharmaceutical formulations.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (FDA, EMA).
• Pharmaceutical Quality Control: Ensures batch-to-batch consistency and verifies the potency of Diltiazem in finished drug products.
• Forensic and Clinical Toxicology: Aids in the precise measurement of Diltiazem levels for therapeutic drug monitoring or overdose cases.
• Stable Isotope Labeling Studies: Serves as a tracer in mechanistic studies to elucidate metabolic pathways.

Basic Information

Product Name	Diltiazem-D6
CAS No.	1242184-41-3
Molecular Formula	C22H20D6N2O4S
Molecular Weight	~ 414.53 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-D6; Diltiazem (hexadeuterated); Diltiazem-d6; cis-(+)-Diltiazem-D6; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, hexadeuterio-; Tildiem-D6; Herbesser-D6; Cardizem-D6
EINECS	Contact for details

Quality Control

Our Diltiazem-D6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, chemical purity, and isotopic enrichment. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, which is essential for audit trails and regulatory submissions in GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.