Description

25-o-Deacetyl-23-o-Acetyl Rifabutin is a key chemical intermediate and derivative of the potent antibiotic rifabutin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel anti-tuberculosis agents and the study of structure-activity relationships. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of advanced antimicrobial therapies and high-purity reference standards.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of rifabutin analogs and next-generation antibiotics.
• Research & Development: Used in biochemical and pharmacological studies to investigate mechanisms of action against mycobacterial infections.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the production pathway for specialized antibiotic formulations.
• Chemical Biology: A tool compound for probing bacterial RNA polymerase inhibition and related biological pathways.

Basic Information

Product Name	25-o-Deacetyl-23-o-Acetyl Rifabutin
CAS No.	1242076-43-2
Molecular Formula	C48H66N4O12
Molecular Weight	891.06 g/mol
Synonyms	Rifabutin 25-Deacetyl-23-acetate; 23-O-Acetyl-25-deacetylrifabutin; 25-Desacetyl-23-acetyl Rifabutin; LM-427 Derivative; Ansamycin Derivative; Rifamycin SV Derivative; Antibiotic LM 427 Intermediate
EINECS	Contact for details

Quality Control

Our 25-o-Deacetyl-23-o-Acetyl Rifabutin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Orange to Red Powder
Identification (IR)	Conforms to Reference Spectrum
Identification (HPLC)	Retention time corresponds to Reference Standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.