Description

Perindopril-D4 Acyl--D-Glucuronide is a high-purity, stable isotope-labeled metabolite of the antihypertensive drug Perindopril. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bioanalysts requiring definitive data for method validation and drug development.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in LC-MS/MS and HPLC methods for the precise quantification of Perindopril and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Metabolite Profiling & Identification: Aids in the structural confirmation and quantification of the acyl glucuronide metabolite pathway of Perindopril.
• Method Development & Validation: Critical for developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control & Forensic Analysis: Used in specialized testing laboratories for the accurate detection of Perindopril and related substances.
• Reference Standard for Quality Control: Serves as a certified reference material (CRM) for in-house quality control of pharmaceutical formulations and raw materials.

Basic Information

Item	Details
Product Name	Perindopril-D4 Acyl--D-Glucuronide
CAS No.	1241977-12-7
Molecular Formula	C27H38D4N2O11
Molecular Weight	Approx. 558.62 g/mol
Synonyms	(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid, Acyl-β-D-Glucuronide, Deuterated (D4); Perindopril D4 Acyl Glucuronide; Perindopril-d4 Glucuronide; Perindopril Acyl Glucuronide-d4; Perindopril Metabolite Standard-d4; S 9780-D4 Acyl Glucuronide; Isotopically Labeled Perindopril Glucuronide.
EINECS	Contact for details

Quality Control

Every batch of Perindopril-D4 Acyl--D-Glucuronide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our rigorous quality testing ensures compliance with the highest standards for isotopic purity, chemical purity, and stability, suitable for GLP/GMP environments. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from NMR, HPLC, LC-MS, and other relevant tests.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium, D)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.