Description

(2R)-2-(3,5-Difluorophenyl)Pyrrolidine is a high-purity chiral pyrrolidine derivative, a critical building block in modern pharmaceutical and agrochemical research. Its value lies in its role as a versatile intermediate for synthesizing complex molecules with specific stereochemistry, enabling the development of targeted active ingredients. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to create novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control reaction stereoselectivity.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in the design of chemical probes for studying biological pathways and protein function.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge synthetic methodology and medicinal chemistry projects.

Basic Information

Product Name	(2R)-2-(3,5-Difluorophenyl)Pyrrolidine
CAS No.	1241683-70-4
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	(R)-2-(3,5-Difluorophenyl)pyrrolidine; (2R)-2-(3,5-Difluorophenyl)-1-pyrrolidine; (R)-3,5-Difluoro-α-(2-pyrrolidinyl)benzene; 1241683-70-4; (R)-2-(3,5-Difluorophenyl)pyrrolidine; Pyrrolidine, 2-(3,5-difluorophenyl)-, (2R)-
EINECS	Contact for details

Quality Control

Our (2R)-2-(3,5-Difluorophenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing full specifications, including enantiomeric excess (ee), is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.