Description

(S)-n-Boc-2-(3,4-Dichlorophenyl)Glycine is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a dichlorophenyl side chain. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, particularly in areas requiring specific stereochemistry and halogenated aromatic motifs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetics Synthesis: Used to incorporate a constrained, hydrophobic amino acid analog into peptide chains to enhance stability, bioavailability, and binding affinity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various protease enzymes.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and enzyme mechanisms where a halogenated aromatic probe is beneficial.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke APIs for clinical trials.

Basic Information

Product Name	(S)-n-Boc-2-(3,4-Dichlorophenyl)Glycine
CAS No.	1241678-17-0
Molecular Formula	C₁₃H₁₅Cl₂NO₄
Molecular Weight	320.17 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-(3,4-dichlorophenyl)acetic acid; Boc-(S)-3,4-Dichlorophenylglycine; (S)-N-Boc-3,4-Dichlorophenylglycine; (S)-2-(tert-Butoxycarbonylamino)-2-(3,4-dichlorophenyl)acetic acid; (S)-N-(tert-Butoxycarbonyl)-3,4-dichlorophenylglycine; (S)-Boc-Dichlorophenylglycine; (S)-Boc-3,4-Cl₂-Phg-OH
EINECS	Contact for details

Quality Control

Our production of (S)-n-Boc-2-(3,4-Dichlorophenyl)Glycine adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if opened, and desiccate if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.