Description

(±)-2,2-Difluoro-1-Methylcyclopropanol is a versatile fluorinated cyclopropanol derivative, a key chiral building block in advanced organic synthesis. Its unique structure, featuring a difluorinated cyclopropane ring, is critical for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial synthon for constructing fluorinated analogs of drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the difluorocyclopropane moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers and advanced materials with tailored surface properties.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in stereoselective synthesis due to its rigid, three-dimensional structure.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity and transformations of fluorinated small rings in academic and industrial R&D settings.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display and lighting applications.

Basic Information

Product Name	(±)-2,2-Difluoro-1-Methylcyclopropanol
CAS No.	1241675-78-4
Molecular Formula	C4H6F2O
Molecular Weight	108.09 g/mol
Synonyms	1-Methyl-2,2-difluorocyclopropanol; 2,2-Difluoro-1-methylcyclopropan-1-ol; rac-2,2-Difluoro-1-methylcyclopropanol; DL-2,2-Difluoro-1-methylcyclopropanol; (±)-1-Methyl-2,2-difluorocyclopropan-1-ol; Difluoromethylcyclopropanol
EINECS	Contact for details

Quality Control

Our (±)-2,2-Difluoro-1-Methylcyclopropanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Reported (for chiral separation grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.