Description

1’-Epi-Benazeprilat Acyl-β-D-Glucuronide is a key metabolite and reference standard of the active form of the antihypertensive drug benazepril. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies for bioanalytical method development, metabolite identification, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of benazepril and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, clearance mechanisms, and bioavailability of benazepril in preclinical and clinical research.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS or HPLC methods for accurate quantification in plasma, serum, or urine samples.
• Impurity Profiling: Employed to identify and characterize process-related or degradation impurities in benazepril active pharmaceutical ingredient (API) and finished dosage forms.
• Regulatory Submissions: Provides critical data to support Investigational New Drug (IND) and New Drug Application (NDA) filings with regulatory bodies like the FDA and EMA.
• Toxicology Studies: Aids in understanding the safety profile and potential toxic metabolites associated with benazepril therapy.

Basic Information

Product Name	1’-Epi-Benazeprilat Acyl-β-D-Glucuronide
CAS No.	1240792-52-2
Molecular Formula	C30H36N2O10
Molecular Weight	584.62 g/mol
Synonyms	1'-Epi-Benazeprilat Acyl-β-D-Glucuronide; Benazeprilat 1'-β-D-Glucuronide (Epi isomer); (3S)-3-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 1-(β-D-Glucopyranuronosyl) ester; Benazepril Metabolite Glucuronide; Acyl Glucuronide of Benazeprilat
EINECS	Contact for details

Quality Control

This high-purity reference material is manufactured under strict quality control conditions suitable for research and analytical use. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, purity, and identification tests conducted via HPLC, NMR, and MS. Our quality system is designed to support GMP/GLP-compliant research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.