Description

R-4-Boc-2-Phenylpiperazine is a high-purity, protected piperazine derivative of significant importance in modern synthetic organic chemistry. This compound serves as a versatile and critical building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, such as antipsychotics and antidepressants.
• Medicinal Chemistry Scaffold: Used to introduce the 2-phenylpiperazine pharmacophore into new chemical entities during structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Employed in the design and construction of peptidomimetics and constrained peptides due to its rigid, nitrogen-containing heterocyclic structure.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Utilized in the development of new herbicides and fungicides that incorporate nitrogen heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	R-4-Boc-2-Phenylpiperazine
CAS No.	1240584-34-2
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(R)-1-Boc-4-Phenylpiperazine; (R)-1-tert-Butoxycarbonyl-4-phenylpiperazine; (R)-4-Phenyl-1-(tert-butoxycarbonyl)piperazine; (R)-N-Boc-4-phenylpiperazine; (R)-tert-Butyl 4-phenylpiperazine-1-carboxylate; 1-Phenyl-4-(tert-butoxycarbonyl)piperazine, (R)-; R-(-)-1-Boc-4-phenylpiperazine
EINECS	Contact for details

Quality Control

Our R-4-Boc-2-Phenylpiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and chiral excess is provided with every shipment to guarantee reproducible results and supply chain integrity for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.