Description

1-Bromo-3-Fluoro-2-Methoxy-4-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective cross-coupling reactions and further functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and complex intermediates. Its specific structure makes it a critical reagent for constructing molecules with tailored biological and physical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form biaryl and other complex structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces in medicinal chemistry.
• Fluorine Chemistry: The presence of a fluorine atom makes it a valuable compound for studying structure-activity relationships (SAR) and metabolic pathways in drug discovery.

Basic Information

Item	Details
Product Name	1-Bromo-3-Fluoro-2-Methoxy-4-Methylbenzene
CAS No.	1239591-03-7
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	2-Bromo-6-Fluoro-3-Methoxytoluene; 3-Bromo-5-Fluoro-2-Methoxy-1-Methylbenzene; 4-Methyl-1-Bromo-3-Fluoro-2-Methoxybenzene; 1-Methyl-2-Bromo-6-Fluoro-3-Methoxybenzene; 2-Methoxy-4-methyl-1-bromo-3-fluorobenzene; 3-Fluoro-2-methoxy-4-methylbromobenzene; 1-Bromo-3-fluoro-2-methoxy-4-methyl-benzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-Fluoro-2-Methoxy-4-Methylbenzene is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.