Description

2-Bromo-1-(Difluoromethoxy)-3-Fluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents, makes it a valuable precursor for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and insecticides, where the fluorine and difluoromethoxy groups enhance biological activity and environmental stability.
• Material Science Research: Used in the synthesis of specialty polymers and liquid crystals, where its aromatic core and halogenated side chains can modify material properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of difluoromethoxy and fluorine substituents on aromatic system reactivity and electronic properties.

Basic Information

Product Name	2-Bromo-1-(Difluoromethoxy)-3-Fluorobenzene
CAS No.	1239492-22-8
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-2-(difluoromethoxy)-4-fluorobenzene; 2-Bromo-α,α-difluoro-3-fluoroanisole; 3-Fluoro-2-bromo-α,α-difluoroanisole; Benzene, 2-bromo-1-(difluoromethoxy)-3-fluoro-; 4-Fluoro-2-(difluoromethoxy)bromobenzene; 2-(Difluoromethoxy)-4-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(Difluoromethoxy)-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Due to its nature as a strong acid/organic solvent and highly volatile compound, it is recommended to store at controlled room temperature (15-25°C) under an inert atmosphere if necessary for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.