Description

2-Chloro-4-(3-Methoxyphenyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzonitrile core substituted with chloro and methoxyphenyl groups. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific molecular architecture enables precise chemical transformations. Pharmaceutical R&D and fine chemical manufacturers need this intermediate for developing new therapeutic agents, particularly in areas requiring sophisticated aromatic nitrile chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its aromatic nitrile functionality.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and material science.
• Functional Material Development: Employed in the research of organic electronic materials and liquid crystals due to its rigid, substituted aromatic structure.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	2-Chloro-4-(3-Methoxyphenyl)Benzonitrile
CAS No.	1237081-74-1
Molecular Formula	C14H10ClNO
Molecular Weight	243.69 g/mol
Synonyms	2-Chloro-4-(3-methoxyphenyl)benzonitrile; 4-(3-Methoxyphenyl)-2-chlorobenzonitrile; 2-Chloro-4-(3'-methoxy[1,1'-biphenyl]-3-yl)benzonitrile (related); Benzonitrile, 2-chloro-4-(3-methoxyphenyl)-; (2-Chloro-4-(3-methoxyphenyl)phenyl)methanenitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(3-Methoxyphenyl)Benzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting all critical parameters are available upon request, providing full traceability and compliance assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.