Description

(-)-o-Desmethyl-N,n-Bisdesmethyltramadol is a high-purity, advanced pharmaceutical intermediate and reference standard. This compound is critical for analytical research, method development, and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers specializing in controlled substance analysis and metabolite studies.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of tramadol and its metabolites in research and forensic toxicology.
• Metabolite Research: Serves as a key metabolite standard in pharmacokinetic and pharmacodynamic studies to understand drug metabolism pathways.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for impurity profiling and bioanalysis.
• Chemical Synthesis Intermediate: Acts as a building block in the research-scale synthesis of novel analgesic compounds or labeled analogs for tracer studies.
• Quality Control Testing: Employed in pharmaceutical QC laboratories to confirm the identity and purity of related substances in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(-)-o-Desmethyl-N,n-Bisdesmethyltramadol
CAS No.	1235568-21-4
Molecular Formula	C15H23NO2
Molecular Weight	249.35 g/mol
Synonyms	(-)-O-Desmethyl-N,N-bisdesmethyltramadol; O-Desmethyl-N,N-didesmethyltramadol; Tramadol Metabolite M4; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; 1-(3-Methoxyphenyl)-2-[(dimethylamino)methyl]cyclohexan-1-ol
EINECS	Contact for details

Quality Control

Our (-)-o-Desmethyl-N,n-Bisdesmethyltramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.