Description

T-Boc-Aminoxy-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (T-Boc) protected aminoxy group and a terminal azide. This compound is engineered to facilitate the site-specific conjugation of biomolecules, offering a versatile tool for constructing complex molecular architectures. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced materials science, where precise and stable cross-linking is required.

Application

• Bioconjugation and ADC Development: Enables the controlled, site-specific coupling of antibodies, proteins, or peptides with cytotoxic drugs, fluorophores, or other payloads via orthogonal click chemistry and oxime ligation.
• PEGylation Reagent: Serves as a functionalized PEG spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic peptides and proteins.
• Click Chemistry Scaffold: The terminal azide group readily participates in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) for modular synthesis of dendrimers, polymers, and surface coatings.
• Proteomics Research: Used as a chemical probe for labeling and enriching biomolecules through oxime formation with carbonyl groups (e.g., in glycans or oxidized proteins).
• Hydrogel and Biomaterial Fabrication: Acts as a cross-linking agent in the development of biocompatible hydrogels and scaffolds for tissue engineering and drug delivery systems.
• Diagnostic Reagent Synthesis: Facilitates the creation of stable conjugates for immunoassays, biosensors, and in vivo imaging agents.

Basic Information

Product Name	T-Boc-Aminoxy-Peg3-Azide
CAS No.	1235514-15-4
Molecular Formula	C18H35N5O7
Molecular Weight	433.51 g/mol
Synonyms	1-Azido-3,6,9-trioxa-12-aminododecane 12-(tert-butoxycarbonylaminooxy)acetate; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-azido-3,6,9-trioxa-12-((((1,1-dimethylethoxy)carbonyl)amino)oxy)-12-oxododecyl ester; T-Boc-NH-O-PEG3-azide; Boc-Aminoxy-PEG3-N3; tert-Butyl (12-azido-3,6,9-trioxa-12-oxododecyl)carbamate; Azido-PEG3-Boc-Aminoxy; Heterobifunctional PEG linker Boc-Aminoxy-PEG3-Azide
EINECS	Contact for details

Quality Control

Our T-Boc-Aminoxy-Peg3-Azide is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.