Description

(2S,3’S)-n-[3-T-Butoxycarbonyl-3-Benzyloxycarbonylamino-Propyl]]Azetidine-2-Carboxylic Acid, T-Butyl Ester is a sophisticated, multi-functional chiral building block designed for advanced pharmaceutical synthesis. This compound is critical for constructing complex peptide-like structures and constrained amino acid analogs, offering precise stereochemical control. It is primarily utilized by research and development chemists and process development teams in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and therapeutic peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex, biologically active molecules and peptide-based therapeutics.
• Peptidomimetic Research: Used to introduce constrained azetidine scaffolds into peptide chains to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying protein-protein interactions and cellular pathways.
• Process Chemistry & Scale-Up: Suitable for use in route development and optimization for the commercial manufacturing of target drug candidates.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical suppliers offering bespoke synthesis services.

Basic Information

Product Name	(2S,3’S)-n-[3-T-Butoxycarbonyl-3-Benzyloxycarbonylamino-Propyl]]Azetidine-2-Carboxylic Acid, T-Butyl Ester
CAS No.	1235453-07-2
Molecular Formula	C24H36N2O6
Molecular Weight	448.56 g/mol
Synonyms	(2S,3'S)-N-[3-[(tert-Butoxycarbonyl)amino]-3-(benzyloxycarbonylamino)propyl]azetidine-2-carboxylic acid tert-butyl ester; Boc-Aze(Boc)-OBzl derivative (protected form); tert-Butyl (2S,3'S)-2-[(3-[(tert-butoxycarbonyl)amino]-3-(benzyloxycarbonylamino)propyl]carbamoyl]azetidine-1-carboxylate; Protected Azetidine-2-carboxylic Acid Derivative; N-Protected Azetidine Amino Acid Ester; Boc-Azetidine(Boc)-OH-OBzl tert-Butyl Ester; CAS 1235453-07-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request. We adhere to a cGMP-compliant quality management system to ensure traceability and batch-to-batch consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.