Description

n-Fmoc-2,6-Difluoro-L-Phenylalanine is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique steric and electronic properties of a difluorinated phenyl ring into peptide sequences, which can significantly alter biological activity and metabolic stability. It is an essential building block for pharmaceutical researchers and peptide chemists developing novel therapeutic peptides, peptidomimetics, and protein engineering tools.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of fluorinated peptide-based drug candidates, including protease inhibitors, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Used to create stable peptide mimics where the 2,6-difluorophenyl moiety enhances binding affinity, selectivity, and resistance to enzymatic degradation.
• Chemical Biology & Proteomics: Incorporation into activity-based probes and affinity tags to study protein function and interactions.
• Agrochemical Research: Building block for the development of novel fluorinated bioactive peptides with potential herbicidal or insecticidal properties.
• Material Science: Potential monomer for creating specialized fluorinated polymers and biomaterials with unique surface properties.

Basic Information

Product Name	n-Fmoc-2,6-Difluoro-L-Phenylalanine
CAS No.	1235005-44-3
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-2,6-Difluoro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-difluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2,6-difluorophenyl)propanoic acid; Fmoc-Dif-Phe-OH; Fmoc-2,6-F2-Phe-OH; N-Fmoc-2,6-difluorophenylalanine; Fmoc-L-2,6-difluorophenylalanine; Protected 2,6-difluoro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-2,6-Difluoro-L-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.