Description

(2R)-2-(Fmoc-Amino)-5-Hexynoic Acid is a non-natural, chiral amino acid derivative featuring a terminal alkyne functional group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the site-specific introduction of bioorthogonal handles for conjugation and labeling. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and chemical development sectors for creating novel peptide-based therapeutics, diagnostic probes, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/t-Bu strategy, allowing for the controlled elongation of peptide chains.
• Peptide Conjugation & Bioconjugation: The terminal alkyne moiety enables efficient, site-specific modification via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) "click" chemistry.
• Chemical Biology & Probe Development: Used to synthesize peptide probes for studying protein-protein interactions, enzyme activity, and cellular localization.
• Pharmaceutical Research: Enables the development of peptide-drug conjugates (PDCs) and other targeted therapeutic agents with improved pharmacokinetic properties.
• Material Science: Serves as a monomer for creating functionalized polymers and surfaces with specific biological activity or recognition properties.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	(2R)-2-(Fmoc-Amino)-5-Hexynoic Acid
CAS No.	1234692-66-0
Molecular Formula	C22H21NO4
Molecular Weight	363.41 g/mol
Synonyms	Fmoc-D-Homopropargylglycine-OH; Fmoc-D-Hpg-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hex-5-ynoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homopropargylglycine; Fmoc-D-2-aminohex-5-ynoic acid; D-Fmoc-homopropargylglycine; Fmoc-D-HomoPg-OH
EINECS	Contact for details

Quality Control

Our (2R)-2-(Fmoc-Amino)-5-Hexynoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.