Description

3-(Cbz-Amino)Cyclobutanecarboxylic Acid is a protected amino acid derivative featuring a cyclobutane ring, a valuable conformationally constrained scaffold in medicinal chemistry. This compound serves as a critical chiral building block for the synthesis of novel peptide mimetics and small molecule drug candidates. It is primarily utilized by pharmaceutical R&D and process chemistry teams for developing protease inhibitors, receptor modulators, and other bioactive molecules where the rigid cyclobutane structure is leveraged to influence potency and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and central nervous system (CNS) diseases.
• Peptidomimetic Synthesis: Used to construct non-natural amino acid residues in peptides to enhance bioavailability, selectivity, and resistance to enzymatic degradation.
• Protease Inhibitor Development: Employed as a core scaffold or side-chain component in the design of inhibitors for various protease targets.
• Chemical Biology Probes: Serves as a building block for creating tool compounds to study protein function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from preclinical to commercial.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	3-(Cbz-Amino)Cyclobutanecarboxylic Acid
CAS No.	1234615-96-3
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	1-Carboxy-3-[(benzyloxycarbonyl)amino]cyclobutane; 3-[(Benzyloxycarbonyl)amino]cyclobutanecarboxylic Acid; 3-(N-Cbz-Amino)cyclobutanecarboxylic Acid; (Z)-3-Aminocyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-; Cbz-3-Amino-cyclobutanecarboxylic Acid; 3-Amino-1-cyclobutanecarboxylic acid N-Cbz derivative
EINECS	Contact for details

Quality Control

Our 3-(Cbz-Amino)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, impurities, and physical characteristics to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under inert atmosphere for long-term storage to maintain optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.