Description

(R)-Methyl 3-Acetamido-4-(2,4,5-Trifluorophenyl)Butanoate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enantiomerically pure compounds. This product is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of fluorinated drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of complex, fluorinated active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes, leveraging its acetamido and trifluorophenyl motifs.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Drug Candidate Optimization: Employed in medicinal chemistry for structure-activity relationship (SAR) studies, particularly for compounds targeting metabolic and neurological disorders.
• Pre-clinical & Clinical Trial Material: Supplied under controlled conditions for the production of materials used in pre-clinical studies and early-phase clinical trials.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-Methyl 3-Acetamido-4-(2,4,5-Trifluorophenyl)Butanoate
CAS No.	1234321-83-5
Molecular Formula	C13H13F3NO3
Molecular Weight	288.24 g/mol
Synonyms	Methyl (3R)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate; (R)-Methyl 3-Acetamido-4-(2,4,5-trifluorophenyl)butyrate; (3R)-3-(Acetylamino)-4-(2,4,5-trifluorophenyl)butanoic Acid Methyl Ester; (R)-3-Acetamido-4-(2,4,5-trifluorophenyl)butyric Acid Methyl Ester; (R)-Methyl 3-Acetylamino-4-(2,4,5-trifluorophenyl)butanoate; (Sitagliptin Intermediate Derivative); Fluorinated Chiral Butanoate Ester
EINECS	Contact for details

Quality Control

Our (R)-Methyl 3-Acetamido-4-(2,4,5-Trifluorophenyl)Butanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.