Description

α-Maleimidopropionyl-ω-Succinimidyl-24(Ethylene Glycol) is a heterobifunctional, amine-to-sulfhydryl crosslinking reagent featuring a hydrophilic polyethylene glycol (PEG) spacer. This compound is engineered to enable the stable and site-specific conjugation of biomolecules, such as antibodies, peptides, and proteins, for advanced research and therapeutic development. It is a critical tool for scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: Facilitates the stable attachment of cytotoxic payloads to monoclonal antibodies via amine and thiol groups.
• Protein and Peptide Labeling: Used for fluorescent or enzymatic tagging of proteins for imaging, detection, and diagnostic applications.
• Surface Immobilization: Enables the covalent attachment of proteins or other ligands to amine-functionalized surfaces, chips, or nanoparticles for biosensor development.
• PEGylation Reagent: Acts as a heterobifunctional PEG spacer to modify biomolecules, improving solubility and stability while reducing immunogenicity.
• Biomolecule Crosslinking: Creates stable conjugates between different proteins, peptides, or oligonucleotides for structural studies or functional complexes.
• Diagnostic Reagent Synthesis: A key component in the manufacture of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassay reagents.

Basic Information

Product Name	α-Maleimidopropionyl-ω-Succinimidyl-24(Ethylene Glycol)
CAS No.	1234177-83-3
Molecular Formula	C58H96N4O28
Molecular Weight	1297.4 g/mol
Synonyms	NHS-PEG24-MAL; Maleimide-PEG24-NHS Ester; SM(PEG)24; Succinimidyl-[(N-maleimidopropionamido)-tetracosaethyleneglycol] ester; 24-Unit PEG NHS-Maleimide Crosslinker; MAL-PEG24-NHS; Amine-to-Sulfhydryl Heterobifunctional PEG Crosslinker; α-Maleimidopropionyl-ω-succinimidyl-24(ethylene glycol)
EINECS	Contact for details

Quality Control

Our α-Maleimidopropionyl-ω-Succinimidyl-24(Ethylene Glycol) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive bioconjugation applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and functional validation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional NHS)	≥ 90%
Assay (Functional Maleimide)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.