Description

1-(2-Amino-5-Bromophenyl)-2,2,2-Trifluoroethanone is a high-purity, multifunctional aromatic building block featuring both an amino group and a trifluoroacetyl moiety. This compound is of significant value in advanced organic synthesis, particularly for constructing complex heterocyclic scaffolds and as a precursor for active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for its unique reactivity profile.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: The amino and carbonyl groups make it a valuable starting point for synthesizing novel chelating ligands and organocatalysts.
• Fluorinated Compound Library: Essential for medicinal chemistry programs focused on building diverse libraries of fluorinated compounds to explore structure-activity relationships (SAR).

Basic Information

Product Name	1-(2-Amino-5-Bromophenyl)-2,2,2-Trifluoroethanone
CAS No.	1233967-22-0
Molecular Formula	C8H5BrF3NO
Molecular Weight	268.03 g/mol
Synonyms	2-Amino-5-bromo-α,α,α-trifluoroacetophenone; 2'-Amino-5'-bromo-2,2,2-trifluoroacetophenone; 1-(2-Amino-5-bromophenyl)-2,2,2-trifluoroethan-1-one; 5-Bromo-2-amino-α,α,α-trifluoroacetophenone; 2-Amino-α,α,α-trifluoro-5-bromoacetophenone; 5-Bromo-2-aminophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our production of 1-(2-Amino-5-Bromophenyl)-2,2,2-Trifluoroethanone adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established internal specifications, which typically include identity confirmation, assay (purity), and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.