Description

tert-Butyl 4-(Isonicotinamido)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with an isonicotinamide moiety. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas targeting the central nervous system and infectious diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those with piperidine-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• API (Active Pharmaceutical Ingredient) Development: Serves as a building block in the multi-step synthesis of complex active ingredients.
• Protease Inhibitor Synthesis: Potential application in the development of inhibitors for various enzymatic targets.
• Ligand Synthesis for Receptor Studies: Useful for creating ligands in neurological and biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 4-(Isonicotinamido)Piperidine-1-Carboxylate
CAS No.	1233958-89-8
Molecular Formula	C16H23N3O3
Molecular Weight	305.37 g/mol
Synonyms	1-Boc-4-(isonicotinamido)piperidine; 4-(Isonicotinamido)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(pyridine-4-carboxamido)piperidine-1-carboxylate; 1-N-Boc-4-(isonicotinamido)piperidine; 4-(Isonicotinoylamino)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(isonicotinamido)piperidine; 1233958-89-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Isonicotinamido)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring suitability for use in advanced pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.