Description

Menaquinone 7-D7 CAS NO 1233937-31-9 is a deuterium-labeled isotopologue of Vitamin K2 (menaquinone-7), a critical cofactor for the activation of proteins involved in blood coagulation and bone metabolism. This high-purity, stable-labeled compound is essential for use as an internal standard in quantitative mass spectrometry (LC-MS/MS) analysis, ensuring unparalleled accuracy and reliability in research and diagnostic assays. It is primarily utilized by analytical laboratories, pharmaceutical R&D departments, and clinical research organizations focused on vitamin K metabolism, cardiovascular health, and osteoporosis studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in bioanalytical method development and validation for accurate measurement of endogenous menaquinone-7 levels.
• Clinical Research & Diagnostics: Enables precise quantification of Vitamin K2 in human serum, plasma, and tissues for studies on bone density, vascular calcification, and nutritional status.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drug candidates targeting vitamin K-dependent pathways.
• Metabolic Pathway Tracing: Facilitates advanced research into the absorption, distribution, metabolism, and excretion (ADME) of Vitamin K2 using deuterium as a stable tracer.
• Nutraceutical & Food Science: Supports the accurate assay of Vitamin K2 content in fortified foods, dietary supplements, and functional ingredients.
• Quality Control & Reference Material: Serves as a certified reference material (CRM) for calibrating laboratory equipment and ensuring data integrity in regulated environments.

Basic Information

Product Name	Menaquinone 7-D7
CAS No.	1233937-31-9
Molecular Formula	C46H57D7O2
Molecular Weight	653.0 g/mol (approx.)
Synonyms	Vitamin K2 (MK-7)-D7; Menaquinone-7-D7; MK-7-D7; all-trans-Menaquinone-7-D7; 2-Methyl-3-all-trans-heptaprenyl-1,4-naphthoquinone-D7; Deuterated Vitamin K2; [D7]-Menaquinone-7; Stable Isotope-Labeled Menaquinone-7
EINECS	Contact for details

Quality Control

Our Menaquinone 7-D7 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity (by HPLC), and confirming identity and potency. We support compliance with ISO 17034 standards for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular ion pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95% (by NMR)
Solubility	Soluble in chloroform, DMSO; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.