Description

2-Ethoxy-4-Fluorobenzotrifluoride is a high-value fluorinated aromatic building block characterized by its trifluoromethyl and ethoxy substituents. This compound matters for its role in facilitating the synthesis of complex molecules, offering unique electronic and steric properties that are critical in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing diverse chemical libraries for screening.

Basic Information

Product Name	2-Ethoxy-4-Fluorobenzotrifluoride
CAS No.	1233541-58-6
Molecular Formula	C9H8F4O
Molecular Weight	208.15 g/mol
Synonyms	1-Ethoxy-2-fluoro-4-(trifluoromethyl)benzene; 4-Fluoro-2-ethoxybenzotrifluoride; 2-Fluoro-4-(trifluoromethyl)phenetole; 4-Fluoro-α,α,α-trifluoro-2-ethoxytoluene; 2-Ethoxy-α,α,α,4-tetrafluorotoluene; Benzene, 1-ethoxy-2-fluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-4-Fluorobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to the presence of fluoride/strong alkali reactive groups, ensure proper segregation from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Refractive Index (n20D)	1.430 - 1.450
Density (20°C)	1.30 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.