Description

3-Chloro-5-Fluorophenylacetylene is a high-purity, halogenated aromatic alkyne building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents on the phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise molecular scaffolds for drug discovery, crop protection agents, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogenated phenylacetylene core contributes to bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems for optoelectronic applications.
• Click Chemistry: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and library synthesis in drug discovery.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	3-Chloro-5-Fluorophenylacetylene
CAS No.	1233506-04-1
Molecular Formula	C8H4ClF
Molecular Weight	154.57 g/mol
Synonyms	1-Chloro-3-fluoro-5-ethynylbenzene; (3-Chloro-5-fluorophenyl)acetylene; 3-Chloro-5-fluorobenzeneacetylene; 3-Chloro-5-fluoroethynylbenzene; 5-Fluoro-3-chlorophenylacetylene; 3-Fluoro-5-chlorophenylacetylene; 3-Chloro-5-fluorophenyl ethyne; 1-Ethynyl-3-chloro-5-fluorobenzene
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorophenylacetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.