Description

1-Amino-6-Azaspiro[2.5]Octane-6-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and azetidine ring system. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting complex biological pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring constrained, three-dimensional spirocyclic frameworks.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in bifunctional degrader molecules due to its rigid structure and functional handles.
• Peptidomimetic Synthesis: The amino acid ester structure makes it valuable for creating peptide analogs with enhanced metabolic stability and membrane permeability.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for investigating enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material production.

Basic Information

Product Name	1-Amino-6-Azaspiro[2.5]Octane-6-Carboxylic Acid tert-Butyl Ester
CAS No.	1233323-55-1
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	1-Amino-6-azaspiro[2.5]octane-6-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 1-amino-6-azaspiro[2.5]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octan-1-amine; 1-Amino-6-Boc-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-6-carboxylic acid, 1-amino-, 1,1-dimethylethyl ester; Boc-6-azaspiro[2.5]octan-1-amine; Azetidine-spirocyclopropane Building Block
EINECS	Contact for details

Quality Control

Our 1-Amino-6-Azaspiro[2.5]Octane-6-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), chiral purity, and impurity profiles. Our quality commitment supports development from research to commercial scale, with the capability to supply material under cGMP standards for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the container in a freezer at -20°C or below under an inert atmosphere. The material is moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.