Description

Deferasirox Acyl-β-D-Glucuronide is a crucial metabolite of the iron chelator Deferasirox, formed via glucuronidation in the liver. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the safety profile of the parent drug. It serves as a vital reference standard for analytical laboratories, pharmaceutical manufacturers, and research institutions focused on bioanalytical method development, metabolite identification, and regulatory compliance for drug submissions.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative and qualitative analysis of Deferasirox metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and half-life of Deferasirox in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, calibrate, and validate sensitive analytical methods such as LC-MS/MS and HPLC for accurate metabolite quantification.
• Toxicology and Safety Assessment: Aids in evaluating the potential toxicity and safety profile of drug metabolites to ensure patient safety.
• Regulatory Compliance and Submission: Critical for generating reliable data required for regulatory filings with agencies like the FDA and EMA.
• Academic and Clinical Research: Supports fundamental research into iron chelation therapy and the biochemical behavior of glucuronidated drug products.

Basic Information

Item	Detail
Product Name	Deferasirox Acyl-β-D-Glucuronide
CAS No.	1233196-91-2
Molecular Formula	C26H24N3O12
Molecular Weight	570.48 g/mol
Synonyms	Deferasirox Acyl Glucuronide; Deferasirox Glucuronide Metabolite; 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid β-D-glucopyranosiduronic acid; ICL670A Glucuronide; Exjade Metabolite; DFX-Glucuronide; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[(4-{3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl}benzoyl)oxy]oxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Deferasirox Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis, LC-MS confirmation, and NMR structural verification, to ensure identity, potency, and purity meet the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.