Description

Guangxitoxin 1E is a potent and selective peptide toxin that specifically inhibits voltage-gated potassium channels, particularly the Kv2.1 subtype. This high-purity biochemical is critical for advanced neuroscience research and ion channel pharmacology studies. It is an essential tool for researchers in pharmaceutical R&D and academic institutions investigating neurological pathways, cardiac electrophysiology, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of voltage-gated potassium (Kv) channels in neuronal signaling and excitability.
• Cardiac Electrophysiology: Used to investigate the role of Kv2.1 channels in cardiac action potentials and arrhythmogenesis.
• Drug Discovery & Screening: Serves as a reference standard and selective blocker in high-throughput assays for identifying new ion channel modulators.
• Cellular & Molecular Biology: Employed in patch-clamp experiments and other functional assays to characterize channel properties and subunit composition.
• Biochemical Studies: Used in binding studies and structural biology to understand toxin-channel interactions at the molecular level.

Basic Information

Product Name	Guangxitoxin 1E
CAS No.	1233152-82-3
Molecular Formula	C185H281N55O52S7
Molecular Weight	4256.0 g/mol
Synonyms	GxTX-1E; Guangxitoxin-1E; GxTX-1; Kv2.1 Blocker; Potassium Channel Toxin GxTX-1E; ShK-like Toxin GxTX-1E; δ-KTx 2.4
EINECS	Contact for details

Quality Control

Our Guangxitoxin 1E is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional activity. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Biological Activity (IC50, Kv2.1)	≤ 5 nM
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.