Description

Temozolomide Metabolite - Mtic is a key analytical reference standard and a major active metabolite of the chemotherapeutic agent Temozolomide. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in oncology drug development and quality control.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for the quantification of the active metabolite in biological matrices during pharmacokinetic studies.
• Bioanalytical Method Development: Used to develop and validate HPLC, LC-MS, and other analytical methods for drug metabolism and pharmacokinetics (DMPK) research.
• Metabolite Identification & Profiling: Essential for identifying and characterizing the metabolic pathways of Temozolomide in preclinical and clinical studies.
• Impurity Standard: Employed as a known impurity standard in the quality control of Temozolomide active pharmaceutical ingredient (API) and finished drug products.
• Toxicology Studies: Used in safety assessment and toxicological evaluations to understand the profile and impact of the metabolite.
• Academic & Clinical Research: Supports fundamental research into the mechanism of action, resistance, and efficacy of Temozolomide therapy.

Basic Information

Product Name	Temozolomide Metabolite - Mtic
CAS No.	1232679-46-7
Molecular Formula	C6H6N6O2
Molecular Weight	194.15 g/mol
Synonyms	5-Aminoimidazole-4-carboxamide; AIC; MTIC; 5-Amino-1H-imidazole-4-carboxamide; NSC 407347; 5-Amino-4-imidazolecarboxamide; 4(5)-Amino-5(4)-imidazolecarboxamide; 4-Amino-5-imidazolecarboxamide
EINECS	Contact for details

Quality Control

Our Temozolomide Metabolite - Mtic is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, spectroscopic identification (NMR, IR, MS), and determination of residual solvents and impurities to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.