Description

4,4-Difluoro-2-Methoxy-Cyclohexanone is a fluorinated cyclohexanone derivative, a versatile building block in advanced organic synthesis. Its unique structure, featuring both fluorine atoms and a methoxy group, makes it a critical intermediate for introducing specific stereoelectronic properties into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorine atoms can enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals, leveraging its rigid, fluorinated cyclohexane core.
• Asymmetric Synthesis: Employed as a chiral building block or prochiral substrate in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new C-F bond formation reactions and the properties of fluorinated heterocycles.

Basic Information

Product Name	4,4-Difluoro-2-Methoxy-Cyclohexanone
CAS No.	1232060-73-9
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	2-Methoxy-4,4-difluorocyclohexanone; 4,4-Difluoro-2-methoxycyclohexan-1-one; 1-Cyclohexanone, 4,4-difluoro-2-methoxy-; Difluoromethoxycyclohexanone
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-2-Methoxy-Cyclohexanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.