Description

2-(3-Bromo-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis. CAS No. 1231892-80-0.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex organic molecules. Its primary and related applications include:

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and constructing complex molecular libraries.
• Fluorine Chemistry: The presence of both bromine and fluorine makes it a unique synthon for introducing these halogens into target molecules, which can alter physicochemical properties like metabolic stability and lipophilicity.

Basic Information

Product Name	2-(3-Bromo-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1231892-80-0
Molecular Formula	C12H15BBrFO2
Molecular Weight	301.96 g/mol
Synonyms	3-Bromo-2-fluorophenylboronic acid pinacol ester; (3-Bromo-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-bromophenylboronic acid pinacol ester; (2-Fluoro-3-bromophenyl)boronic acid pinacol ester; 3-Bromo-2-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; Pinacol (3-bromo-2-fluorophenyl)boronate; B-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports applications in regulated environments, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.