Description

α-Me-Gly(Propargyl)-Oh is a specialized amino acid derivative featuring a propargyl side chain, a functional group of significant synthetic utility. This compound matters as a versatile building block in advanced organic synthesis, particularly for click chemistry applications via its alkyne moiety. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other high-value molecular constructs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those requiring alkyne-azide cycloaddition (CuAAC) for bioconjugation.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, linear alkyne spacers or as a component in the synthesis of non-natural amino acids for peptide backbone modification.
• Chemical Biology Probes: Serves as a labeling agent or a handle for attaching fluorescent tags, biotin, or other reporter molecules to biomolecules for study.
• Material Science: Potential monomer or cross-linking agent in the synthesis of novel polymers with tailored properties via post-polymerization modification.
• Agrochemical Research: Employed in the synthesis of novel compounds for crop protection and agricultural chemistry.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic synthesis and catalysis studies.

Basic Information

Product Name	α-Me-Gly(Propargyl)-Oh
CAS No.	1231709-27-5
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	2-Amino-2-methyl-4-pentynoic acid; 2-Amino-2-methylpent-4-ynoic acid; (α-Methyl)propargylglycine; 2-Methyl-2-(prop-2-yn-1-ylamino)acetic acid; N-Propargyl-α-aminoisobutyric acid; Aib(Propargyl); N-(Prop-2-yn-1-yl)-2-aminoisobutyric acid
EINECS	Contact for details

Quality Control

Our α-Me-Gly(Propargyl)-Oh is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.