Description

2,5-Difluoro-4-Hydroxyphenylboronic Acid CAS NO 1229584-22-8 is a high-value, multi-functional boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both boronic acid and phenolic hydroxyl groups on a difluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the difluorophenol moiety enhances biological activity and environmental stability.
• Material Science: Building block for synthesizing advanced polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs) requiring precise molecular architecture.
• Chemical Biology & Proteomics: Employed in the development of chemical probes and affinity ligands for studying protein function and enzyme inhibition.
• Suzuki-Miyaura Cross-Coupling: A versatile coupling partner for forming carbon-carbon bonds with aryl/vinyl halides, enabling the construction of complex biaryl structures.
• Research & Development: Essential reagent in medicinal chemistry and process chemistry R&D for exploring new chemical entities and optimizing synthetic routes.

Basic Information

Item	Details
Product Name	2,5-Difluoro-4-Hydroxyphenylboronic Acid
CAS No.	1229584-22-8
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	2,5-Difluoro-4-hydroxybenzeneboronic acid; (2,5-Difluoro-4-hydroxyphenyl)boronic acid; 4-Borono-2,5-difluorophenol; 2,5-Difluoro-4-hydroxy-phenylboronic acid; 2,5-Difluoro-4-hydroxyphenylboronic acid pinacol ester (common derivative); DFHPBA; 1229584-22-8
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and production applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.