Description

Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralizes interleukin-17A (IL-17A), a key cytokine involved in inflammatory pathways. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced biologic therapies. It is primarily utilized by pharmaceutical manufacturers and biotech companies engaged in the research, development, and production of treatments for autoimmune and inflammatory diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis.

Application

• Active Pharmaceutical Ingredient (API) for biologic drug formulation.
• Research and development of novel therapeutics targeting the IL-17 pathway.
• Manufacturing of biosimilar versions of established biologic drugs.
• Pre-clinical and clinical trial material for immunological studies.
• Reference standard for quality control and analytical method development.

Basic Information

Product Name	Secukinumab
CAS No.	1229022-83-6
Molecular Formula	C6524H10064N1736O2036S46
Molecular Weight	Approx. 147 kDa
Synonyms	AIN457; Cosentyx® (trade name); Anti-IL-17A Monoclonal Antibody; IL-17A Inhibitor; Immunoglobulin G1, anti-(human interleukin 17A) (human monoclonal heavy chain), disulfide with human monoclonal light chain, dimer; Recombinant Human Anti-IL-17A IgG1 kappa; Secukinumab (USAN, INN)
EINECS	Contact for details

Quality Control

Our Secukinumab is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting stringent specifications for biologic APIs. Certificates of Analysis (COA) are provided, detailing results for critical quality attributes such as purity by HPLC, biological activity, endotoxin levels, and sterility. We support compliance with cGMP, ICH guidelines, and relevant pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, store at 2-8°C. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Handle under aseptic conditions appropriate for a biologic product.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Assay (Protein Content)	90.0% - 110.0% of label claim
Biological Activity (Cell-based assay)	Within specified range
Endotoxin	< 1.0 EU/mg
pH	5.5 - 6.5 (for solution)
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.