Description

Ethyl 2-(2,4-Difluorophenyl)-2,2-Difluoroacetate is a high-value fluorinated organic ester building block, prized for its unique difluoroacetate moiety and aromatic substitution pattern. This compound is essential for introducing the difluoroacetate functional group into complex molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoroacetate group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Fluorinated Polymer Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, improving material properties like chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: Acts as a versatile reagent in nucleophilic substitution and coupling reactions for constructing complex, fluorinated molecular architectures in academic and industrial R&D.
• Proteolysis-Targeting Chimera (PROTAC) Linker Chemistry: Potential use in the synthesis of bifunctional molecules for targeted protein degradation, a cutting-edge therapeutic modality.

Basic Information

Product Name	Ethyl 2-(2,4-Difluorophenyl)-2,2-Difluoroacetate
CAS No.	1228957-05-8
Molecular Formula	C10H8F4O2
Molecular Weight	236.16 g/mol
Synonyms	2,2-Difluoro-2-(2,4-difluorophenyl)acetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(2,4-difluorophenyl)acetate; Acetic acid, 2,2-difluoro-2-(2,4-difluorophenyl)-, ethyl ester; Ethyl α,α-Difluoro-2,4-difluorophenylacetate; DFPA Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2,4-Difluorophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.