Description

2-((9H-Fluoren-9-Yl)Methyl) 5-tert-Butyl 2,5-Diazabicyclo[4.1.0]Heptane-2,5-Dicarboxylate is a highly specialized, protected diazabicycloheptane derivative, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its value lies in its unique, constrained bicyclic structure, which is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and other therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for constructing complex nitrogen-containing heterocycles found in pharmaceutical candidates.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, a major class of drugs for treating viral infections like HIV and HCV.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies due to its rigid, three-dimensional scaffold.
• Peptidomimetic Research: Acts as a conformationally restricted scaffold to mimic peptide turn structures, enhancing metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized in chiral synthesis where its bicyclic framework can induce stereoselectivity in subsequent chemical transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	2-((9H-Fluoren-9-Yl)Methyl) 5-tert-Butyl 2,5-Diazabicyclo[4.1.0]Heptane-2,5-Dicarboxylate
CAS No.	1228675-23-7
Molecular Formula	C26H30N2O4
Molecular Weight	434.53 g/mol
Synonyms	Fmoc-2,5-Diazabicyclo[4.1.0]heptane-2,5-dicarboxylic acid 5-tert-butyl ester; 2,5-Diazabicyclo[4.1.0]heptane-2,5-dicarboxylic acid, 2-[(9H-fluoren-9-yl)methyl] ester, 5-(1,1-dimethylethyl) ester; 2-[(9H-Fluoren-9-yl)methyl] 5-tert-butyl 2,5-diazabicyclo[4.1.0]heptane-2,5-dicarboxylate; Fmoc-Diazabicycloheptane-Boc; Protected 2,5-Diazabicyclo[4.1.0]heptane; Fmoc-2,5-DABCH-Boc; 2,5-Diazabicyclo[4.1.0]heptane derivative; 2-N-Fmoc-5-N-Boc-2,5-diazabicyclo[4.1.0]heptane
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical R&D and cGMP manufacturing processes. The product undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.