Description

5-Fluoro-4-((Trimethylsilyl)ethynyl)-1H-pyrrolo-[2,3-b]pyridine is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic scaffold with a protected acetylene moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted kinase inhibitors and other biologically active molecules. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile pyrrolopyridine core.
• Bioconjugation & Probe Development: The trimethylsilyl-protected alkyne group serves as a handle for click chemistry reactions, enabling the creation of diagnostic probes or targeted drug conjugates.
• Agrochemical Research: Employed in the discovery and development of new active ingredients with specific biological activity.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system.

Basic Information

Product Name	5-Fluoro-4-((Trimethylsilyl)ethynyl)-1H-Pyrrolo-[2,3-b]Pyridine
CAS No.	1228666-01-0
Molecular Formula	C₁₂H₁₃FN₂Si
Molecular Weight	232.33 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-4-[(trimethylsilyl)ethynyl]-; 5-Fluoro-4-(2-trimethylsilylethynyl)-1H-pyrrolo[2,3-b]pyridine; TMS-Ethynyl Fluoropyrrolopyridine Intermediate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-((Trimethylsilyl)ethynyl)-1H-pyrrolo-[2,3-b]pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.