Description

4-Bromo-5-Chloro-2-Methyl-Benzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic research.
• Agrochemical Synthesis: Used as a building block for developing new herbicides, fungicides, and insecticides with specific modes of action.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers and liquid crystals.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Bromo-5-Chloro-2-Methyl-Benzonitrile
CAS No.	1228376-18-8
Molecular Formula	C8H5BrClN
Molecular Weight	230.49 g/mol
Synonyms	2-Methyl-4-bromo-5-chlorobenzonitrile; 4-Bromo-5-chloro-o-tolunitrile; 5-Chloro-4-bromo-2-methylbenzonitrile; Benzonitrile, 4-bromo-5-chloro-2-methyl-; 2-Methyl-5-chloro-4-bromobenzonitrile; 4-Bromo-5-chloro-2-methylbenzonitrile; (4-Bromo-5-chloro-2-methylphenyl)carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Chloro-2-Methyl-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.