Description

Chlorpromazine-D6 Hydrochloride is a deuterated internal standard of the classic antipsychotic agent, chlorpromazine. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and forensic toxicology. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the precise quantification of chlorpromazine and its metabolites in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Forensic & Clinical Toxicology: Used in assays to confirm and quantify chlorpromazine exposure in cases of overdose, compliance monitoring, or post-mortem investigations.
• Drug Metabolism Research: Facilitates the identification and measurement of metabolite formation pathways and rates.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for chlorpromazine-based drug products.

Basic Information

Product Name	Chlorpromazine-D6 Hydrochloride
CAS No.	1228182-46-4
Molecular Formula	C17H13D6ClN2S•HCl
Molecular Weight	355.34 g/mol (for monoisotopic)
Synonyms	2-Chloro-10-[3-(dimethyl-d6-amino)propyl]phenothiazine Hydrochloride; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-bis(methyl-d3)propan-1-amine Hydrochloride; Chlorpromazine-d6 HCl; Deuterated Chlorpromazine Hydrochloride; CPZ-d6 HCl
EINECS	Contact for details

Quality Control

Our Chlorpromazine-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm structure, deuterium incorporation, and purity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.