Description

5-Bromo-1-Fluoro-3-Iodo-2-Methoxy-Benzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of bromo, fluoro, and iodo substituents on a methoxy-benzene scaffold makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, medicinal chemistry, and the development of novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex aryl-aryl bonds via Suzuki, Stille, or Buchwald-Hartwig cross-coupling reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen atoms provide sites for further functionalization to tune biological activity.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for imaging and diagnostic applications, leveraging the reactivity of the iodine atom for further modifications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical market.

Basic Information

Product Name	5-Bromo-1-Fluoro-3-Iodo-2-Methoxy-Benzene
CAS No.	1228093-58-0
Molecular Formula	C7H5BrFIO
Molecular Weight	345.92 g/mol
Synonyms	2-Methoxy-5-bromo-1-fluoro-3-iodobenzene; 1-Bromo-4-fluoro-2-iodo-5-methoxybenzene; 5-Bromo-2-fluoro-6-iodoanisole; Benzene, 5-bromo-1-fluoro-3-iodo-2-methoxy-; 2-Bromo-5-fluoro-3-iodoanisole
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Fluoro-3-Iodo-2-Methoxy-Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material compliant with ICH Q7 and other relevant GMP guidelines for advanced intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.