Description

1,2-Difluoro-3,5-Diiodo-4-Methoxybenzene is a highly functionalized, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a valuable precursor for constructing complex molecules via selective cross-coupling and nucleophilic substitution reactions. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting fluorinated bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the difluoro-diiodo motif can impart unique biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as ligands for catalysts or monomers for specialty polymers.
• Cross-Coupling Reactions: The iodine atoms are excellent substrates for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Stille), enabling rapid diversification of the benzene core.
• Fluorination Studies: Used as a model compound or starting material in methodologies studying directed ortho-metalation or nucleophilic aromatic substitution of fluorine.
• Ligand Synthesis: Employed in the preparation of complex, polydentate ligands for coordination chemistry and catalysis.

Basic Information

Product Name	1,2-Difluoro-3,5-Diiodo-4-Methoxybenzene
CAS No.	1228093-55-7
Molecular Formula	C7H4F2I2O
Molecular Weight	399.91 g/mol
Synonyms	4-Methoxy-1,2-difluoro-3,5-diiodobenzene; 3,5-Diiodo-1,2-difluoro-4-methoxybenzene; Benzene, 1,2-difluoro-3,5-diiodo-4-methoxy-; 1,2-Difluoro-4-methoxy-3,5-diiodobenzene; 4-Methoxy-3,5-diiodo-1,2-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-3,5-Diiodo-4-Methoxybenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its light-sensitive nature, handling and storage should minimize exposure to direct light to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.