Description

tert-Butyl ((1R,2R)-2-(4-Bromophenyl)Cyclopropyl)Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its defined stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Asymmetric Synthesis: Employed in the construction of complex, enantiomerically pure molecules due to its rigid cyclopropane ring and defined (1R,2R) configuration.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, chiral active ingredients for crop protection products.

Basic Information

Product Name	tert-Butyl ((1R,2R)-2-(4-Bromophenyl)Cyclopropyl)Carbamate
CAS No.	1228092-36-1
Molecular Formula	C14H18BrNO2
Molecular Weight	312.20 g/mol
Synonyms	(1R,2R)-2-(4-Bromophenyl)cyclopropanamine, N-Boc derivative; 1,1-Dimethylethyl N-[(1R,2R)-2-(4-bromophenyl)cyclopropyl]carbamate; tert-Butyl N-[(1R,2R)-2-(4-bromophenyl)cyclopropyl]carbamate; Boc-(1R,2R)-2-(4-Br-Ph)-cyclopropylamine; (1R,2R)-2-(4-Bromophenyl)cyclopropylcarbamic acid tert-butyl ester; BOC-Protected (1R,2R)-2-(4-Bromophenyl)cyclopropylamine
EINECS	Contact for details

Quality Control

Our tert-Butyl ((1R,2R)-2-(4-Bromophenyl)Cyclopropyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.