Description

L-Lysine-13C6 Hydrochloride is a stable isotope-labeled analog of the essential amino acid L-Lysine, where all six carbon atoms are the 13C isotope. This high-purity compound is critical for advanced quantitative analysis and metabolic research, providing an internal standard for unparalleled accuracy in mass spectrometry. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in proteomics, pharmacokinetics, and stable isotope tracer studies.

Application

• Mass Spectrometry Internal Standard: Serves as a quantitative reference standard in LC-MS/MS and GC-MS analysis for accurate measurement of endogenous L-Lysine levels in biological matrices.
• Metabolic Pathway Tracing: Used in in vivo and in vitro studies to trace lysine metabolism, protein synthesis rates, and nutrient utilization using 13C labeling techniques.
• Pharmaceutical R&D: Essential in drug metabolism and pharmacokinetics (DMPK) studies for developing protein-based therapeutics and amino acid analogs.
• Clinical Research & Diagnostics: Enables precise quantification in research related to metabolic disorders, nutritional status assessment, and biomarker discovery.
• Proteomics & Biomarker Analysis: Facilitates accurate, absolute quantification of proteins and peptides in complex samples through methods like AQUA.

Basic Information

Product Name	L-Lysine-13C6 Hydrochloride
CAS No.	1228077-86-8
Molecular Formula	C613C6H15ClN2O2 • HCl
Molecular Weight	Approx. 227.12 g/mol (for 13C6 labeled form)
Synonyms	(2S)-2,6-Diamino-13C6-hexanoic acid hydrochloride; L-Lysine-13C6 HCl; Lysine-13C6 hydrochloride; (S)-2,6-Diamino-13C6-caproic acid monohydrochloride; 13C6-L-Lysine•HCl; Isotopically labeled L-Lysine HCl; [U-13C6]-L-Lysine hydrochloride; Stable isotope-labeled lysine HCl
EINECS	Contact for details

Quality Control

Our L-Lysine-13C6 Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity, and analytical results from NMR, HPLC, and MS. We adhere to cGMP principles for research-grade materials, ensuring traceability, consistency, and reliability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store at 2-8°C in a cool, dry place. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]20/D: +19° to +22° (c=2 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.