Description

Pyridine, 2-(Bromomethyl)-3,5-Difluoro- is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromomethyl and difluoro substituents, makes it an indispensable reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized pyridine-based ligands used in transition metal catalysis and material science.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The bromomethyl group acts as an effective handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Derivatization Agent: Used to introduce the 2-(bromomethyl)-3,5-difluoropyridine moiety into larger molecules for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Pyridine, 2-(Bromomethyl)-3,5-Difluoro-
CAS No.	1227516-28-0
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	2-(Bromomethyl)-3,5-difluoropyridine; 3,5-Difluoro-2-(bromomethyl)pyridine; 2-Bromomethyl-3,5-difluoropyridine; (3,5-Difluoropyridin-2-yl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of Pyridine, 2-(Bromomethyl)-3,5-Difluoro- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and LC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark environment.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.