Description

2-(5-Chloro-6-Fluoropyridin-3-Yl)Acetonitrile is a high-purity, versatile pyridine-based nitrile building block essential for advanced organic synthesis. This compound is valued for its reactive nitrile group and halogenated pyridine core, enabling the construction of complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(5-Chloro-6-Fluoropyridin-3-Yl)Acetonitrile
CAS No.	1227513-54-3
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	(5-Chloro-6-fluoropyridin-3-yl)acetonitrile; 3-Pyridineacetonitrile, 5-chloro-6-fluoro-; 5-Chloro-6-fluoro-3-pyridineacetonitrile; 2-(5-Chloro-6-fluoropyridin-3-yl)ethanenitrile; 1227513-54-3; 5-Chloro-6-fluoro-pyridin-3-yl-acetonitrile
EINECS	Contact for details

Quality Control

Our 2-(5-Chloro-6-Fluoropyridin-3-Yl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.