Description

4-Iodo-3,5-Dimethylbenzonitrile is a high-purity, halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for applications such as Suzuki-Miyaura cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), especially those requiring halogenated aromatic cores.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the iodo and nitrile functionalities impart specific biological activity.
• Material Science: Serves as a monomer or building block for the synthesis of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to create biaryl and other complex structures.
• Chemical Synthesis: Utilized in organic synthesis laboratories for the introduction of iodine and cyano groups into more complex molecules.
• Ligand & Catalyst Development: Employed in the research and preparation of novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	4-Iodo-3,5-Dimethylbenzonitrile
CAS No.	1227311-09-2
Molecular Formula	C9H8IN
Molecular Weight	257.07 g/mol
Synonyms	3,5-Dimethyl-4-iodobenzonitrile; 4-Iodo-3,5-dimethylbenzenecarbonitrile; Benzonitrile, 4-iodo-3,5-dimethyl-; 1227311-09-2; 4-Iodo-3,5-dimethyl-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Iodo-3,5-Dimethylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.