Description

1-(Phenylsulphonyl)-6-Cyano-7-Azaindole is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1227270-43-0. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, especially within oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted small-molecule drugs, particularly protein kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and selectivity.
• Biochemical Tool Compound: Serves as a reference standard or a core scaffold for probing specific biological pathways and enzyme functions in vitro.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Cyano-7-Azaindole
CAS No.	1227270-43-0
Molecular Formula	C16H9N3O2S
Molecular Weight	307.33 g/mol
Synonyms	6-Cyano-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-6-carbonitrile, 1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-6-cyano-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-6-cyano-7-azaindole; 6-Cyano-1-(phenylsulfonyl)-7-azaindole; 1-(Phenylsulfonyl)-6-cyano-7-azaindole; 1227270-43-0; 7-Azaindole-6-carbonitrile, 1-(phenylsulfonyl)-
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Cyano-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.